| 9/1/2022 | Central Michigan | 44 | at | Oklahoma State (7-6) | 58 | at B12 | ||
| 9/10/2022 | South Alabama (10-3) | 38 | at | Central Michigan | 24 | SBC | ||
| 9/17/2022 | Bucknell (3-8) | 0 | at | Central Michigan | 41 | Pat (1AA) | ||
| 9/24/2022 | Central Michigan | 14 | at | Penn State (11-2) | 33 | at B10 | ||
| 10/1/2022 | Central Michigan | 17 | at | Toledo (9-5,6-3) | 38 | |||
| 10/8/2022 | Ball State (5-7,3-5) | 17 | at | Central Michigan | 16 | |||
| 10/15/2022 | Central Michigan | 28 | at | Akron (2-10,1-7) | 21 | |||
| 10/22/2022 | Bowling Green (6-7,5-3) | 34 | at | Central Michigan | 18 | |||
| 11/2/2022 | Central Michigan | 35 | at | Northern Illinois (3-9,2-6) | 22 | |||
| 11/9/2022 | Buffalo (7-6,5-3) | 27 | at | Central Michigan | 31 | |||
| 11/16/2022 | Western Michigan (5-7,4-4) | 12 | at | Central Michigan | 10 | |||
| 11/25/2022 | Central Michigan | 19 | at | Eastern Michigan (9-4,5-3) | 38 |
| vs Central Michigan | vs Other Opponents | Central Michigan compared to OOs | |
| Record: | 8-4 | 69-70 | |
| Points Scored: | 28.17 | 26.39 | -1.78 |
| Points Allowed: | 24.75 | 27.36 | -2.61 |
| Margin: | 3.42 | -0.97 | -4.39 |
| Total Points: | 52.92 | 53.75 | -0.83 |