| 9/3/2022 | Southern Illinois | 29 | at | Incarnate Word (12-2) | 64 | at SLC | ||
| 9/10/2022 | SE Missouri State (9-3) | 34 | at | Southern Illinois | 31 | OVC | ||
| 9/17/2022 | Southern Illinois | 31 | at | Northwestern (1-11) | 24 | at B10 | ||
| 9/24/2022 | North Dakota (7-5,5-3) | 17 | at | Southern Illinois | 34 | |||
| 10/1/2022 | Southern Illinois | 19 | at | Illinois State (6-5,4-4) | 14 | |||
| 10/8/2022 | Southern Illinois | 38 | at | Missouri State (5-6,3-5) | 21 | |||
| 10/15/2022 | Western Illinois (0-11,0-8) | 7 | at | Southern Illinois | 30 | |||
| 10/22/2022 | Southern Illinois | 24 | at | South Dakota (3-8,2-6) | 27 | |||
| 10/29/2022 | Northern Iowa (6-5,5-3) | 37 | at | Southern Illinois | 36 | |||
| 11/12/2022 | North Dakota State (12-3,7-2) | 21 | at | Southern Illinois | 18 | |||
| 11/19/2022 | Southern Illinois | 21 | at | Youngstown State (7-4,5-3) | 28 |
| vs Southern Illinois | vs Other Opponents | Southern Illinois compared to OOs | |
| Record: | 6-5 | 62-58 | |
| Points Scored: | 26.73 | 28.29 | 1.56 |
| Points Allowed: | 28.27 | 26.27 | 2.00 |
| Margin: | -1.54 | 2.02 | 3.56 |
| Total Points: | 55.00 | 54.56 | 0.44 |