| 9/3/2022 | SE Missouri State (9-3) | 10 | at | Iowa State | 42 | OVC (1AA) | ||
| 9/10/2022 | Iowa State | 10 | at | Iowa (8-5) | 7 | at B10 | ||
| 9/17/2022 | Ohio (10-4) | 10 | at | Iowa State | 43 | MAC | ||
| 9/24/2022 | Baylor (6-7,4-5) | 31 | at | Iowa State | 24 | |||
| 10/1/2022 | Iowa State | 11 | at | Kansas (6-7,3-6) | 14 | |||
| 10/8/2022 | Kansas State (10-4,8-2) | 10 | at | Iowa State | 9 | |||
| 10/15/2022 | Iowa State | 21 | at | Texas (8-5,6-3) | 24 | |||
| 10/29/2022 | Oklahoma (6-7,3-6) | 27 | at | Iowa State | 13 | |||
| 11/5/2022 | West Virginia (5-7,3-6) | 14 | at | Iowa State | 31 | |||
| 11/12/2022 | Iowa State | 14 | at | Oklahoma State (7-6,4-5) | 20 | |||
| 11/19/2022 | Texas Tech (8-5,5-4) | 14 | at | Iowa State | 10 | |||
| 11/26/2022 | Iowa State | 14 | at | TCU (13-2,9-1) | 62 |
| vs Iowa State | vs Other Opponents | Iowa State compared to OOs | |
| Record: | 8-4 | 88-58 | |
| Points Scored: | 20.25 | 33.28 | 13.03 |
| Points Allowed: | 20.17 | 27.19 | -7.02 |
| Margin: | 0.08 | 6.09 | 6.01 |
| Total Points: | 40.42 | 60.47 | -20.05 |