| 9/3/2022 | Notre Dame | 10 | at | Ohio State (11-2) | 21 | at B10 | ||
| 9/10/2022 | Marshall (9-4) | 26 | at | Notre Dame | 21 | SBC | ||
| 9/17/2022 | California (4-8) | 17 | at | Notre Dame | 24 | P12 | ||
| 9/24/2022 | Notre Dame | 45 | at | North Carolina (9-5) | 32 | at ACC | ||
| 10/8/2022 | BYU (8-5) | 20 | at | Notre Dame | 28 | Las Vegas NV | Ind | |
| 10/15/2022 | Stanford (3-9) | 16 | at | Notre Dame | 14 | P12 | ||
| 10/22/2022 | UNLV (5-7) | 21 | at | Notre Dame | 44 | MW | ||
| 10/29/2022 | Notre Dame | 41 | at | Syracuse (7-6) | 24 | at ACC | ||
| 11/5/2022 | Clemson (11-3) | 14 | at | Notre Dame | 35 | ACC | ||
| 11/12/2022 | Notre Dame | 35 | vs | Navy (4-8) | 32 | Baltimore MD | vs AAC | |
| 11/19/2022 | Boston College (3-9) | 0 | at | Notre Dame | 44 | ACC | ||
| 11/26/2022 | Notre Dame | 27 | at | Southern California (11-3) | 38 | at P12 | ||
| 12/30/2022 | Notre Dame | 45 | vs | South Carolina (8-5) | 38 | Jacksonville FL | vs SEC |
| vs Notre Dame | vs Other Opponents | Notre Dame compared to OOs | |
| Record: | 4-9 | 89-65 | |
| Points Scored: | 23.00 | 30.13 | 7.13 |
| Points Allowed: | 31.77 | 25.82 | 5.95 |
| Margin: | -8.77 | 4.31 | 13.08 |
| Total Points: | 54.77 | 55.95 | -1.18 |