| 9/2/2022 | TCU (13-2) | 38 | at | Colorado | 13 | B12 | ||
| 9/10/2022 | Colorado | 10 | at | Air Force (10-3) | 41 | at MW | ||
| 9/17/2022 | Colorado | 7 | at | Minnesota (9-4) | 49 | at B10 | ||
| 9/24/2022 | UCLA (9-4,6-3) | 45 | at | Colorado | 17 | |||
| 10/1/2022 | Colorado | 20 | at | Arizona (5-7,3-6) | 43 | |||
| 10/15/2022 | California (4-8,2-7) | 13 | at | Colorado | 20 | OT | ||
| 10/22/2022 | Colorado | 9 | at | Oregon State (10-3,6-3) | 42 | |||
| 10/29/2022 | Arizona State (3-9,2-7) | 42 | at | Colorado | 34 | |||
| 11/5/2022 | Oregon (10-3,7-2) | 49 | at | Colorado | 10 | |||
| 11/11/2022 | Colorado | 17 | at | Southern California (11-3,8-2) | 55 | |||
| 11/19/2022 | Colorado | 7 | at | Washington (11-2,7-2) | 54 | |||
| 11/26/2022 | Utah (10-4,8-2) | 63 | at | Colorado | 21 |
| vs Colorado | vs Other Opponents | Colorado compared to OOs | |
| Record: | 11-1 | 94-51 | |
| Points Scored: | 44.50 | 33.21 | -11.29 |
| Points Allowed: | 15.42 | 26.14 | -10.72 |
| Margin: | 29.08 | 7.07 | -22.01 |
| Total Points: | 59.92 | 59.35 | 0.57 |