| 9/4/2022 | Florida State (10-3) | 24 | vs | LSU | 23 | New Orleans LA | ACC | |
| 9/10/2022 | Southern (7-5) | 17 | at | LSU | 65 | SWAC (1AA) | ||
| 9/17/2022 | Mississippi State (9-4,4-4) | 16 | at | LSU | 31 | |||
| 9/24/2022 | New Mexico (2-10) | 0 | at | LSU | 38 | MW | ||
| 10/1/2022 | LSU | 21 | at | Auburn (5-7,2-6) | 17 | |||
| 10/8/2022 | Tennessee (11-2,6-2) | 40 | at | LSU | 13 | |||
| 10/15/2022 | LSU | 45 | at | Florida (6-7,3-5) | 35 | |||
| 10/22/2022 | Mississippi (8-5,4-4) | 20 | at | LSU | 45 | |||
| 11/5/2022 | Alabama (11-2,6-2) | 31 | at | LSU | 32 | OT | ||
| 11/12/2022 | LSU | 13 | at | Arkansas (7-6,3-5) | 10 | |||
| 11/19/2022 | UAB (7-6) | 10 | at | LSU | 41 | CUSA | ||
| 11/26/2022 | LSU | 23 | at | Texas A&M (5-7,2-6) | 38 | |||
| 12/3/2022 | LSU | 30 | vs | Georgia (15-0,9-0) | 50 | SEC Championship Atlanta GA | ||
| 1/2/2023 | LSU | 63 | vs | Purdue (8-6) | 7 | Orlando FL | vs B10 |
| vs LSU | vs Other Opponents | LSU compared to OOs | |
| Record: | 4-10 | 107-60 | |
| Points Scored: | 22.50 | 32.49 | 9.99 |
| Points Allowed: | 34.50 | 22.76 | 11.74 |
| Margin: | -12.00 | 9.73 | 21.73 |
| Total Points: | 57.00 | 55.25 | 1.75 |