| 9/2/2022 | Temple (3-9) | 0 | at | Duke | 30 | AAC | ||
| 9/10/2022 | Duke | 31 | at | Northwestern (1-11) | 23 | at B10 | ||
| 9/17/2022 | North Carolina A&T (7-4) | 20 | at | Duke | 49 | BigS (1AA) | ||
| 9/24/2022 | Duke | 27 | at | Kansas (6-7) | 35 | at B12 | ||
| 10/1/2022 | Virginia (3-7,1-6) | 17 | at | Duke | 38 | |||
| 10/8/2022 | Duke | 20 | at | Georgia Tech (5-7,4-4) | 23 | OT | ||
| 10/15/2022 | North Carolina (9-5,6-3) | 38 | at | Duke | 35 | |||
| 10/22/2022 | Duke | 45 | at | Miami-Florida (5-7,3-5) | 21 | |||
| 11/4/2022 | Duke | 38 | at | Boston College (3-9,2-6) | 31 | |||
| 11/12/2022 | Virginia Tech (3-8,1-6) | 7 | at | Duke | 24 | |||
| 11/19/2022 | Duke | 26 | at | Pittsburgh (9-4,5-3) | 28 | |||
| 11/26/2022 | Wake Forest (8-5,3-5) | 31 | at | Duke | 34 | |||
| 12/28/2022 | UCF (9-5) | 13 | vs | Duke | 30 | Annapolis MD | AAC |
| vs Duke | vs Other Opponents | Duke compared to OOs | |
| Record: | 4-9 | 67-79 | |
| Points Scored: | 22.08 | 26.17 | 4.09 |
| Points Allowed: | 32.85 | 27.40 | 5.45 |
| Margin: | -10.77 | -1.23 | 9.54 |
| Total Points: | 54.93 | 53.57 | 1.36 |