| 9/3/2022 | Miami-Ohio | 13 | at | Kentucky (7-6) | 37 | at SEC | ||
| 9/10/2022 | Robert Morris (0-11) | 14 | at | Miami-Ohio | 31 | BigS (1AA) | ||
| 9/17/2022 | Cincinnati (9-4) | 38 | at | Miami-Ohio | 17 | AAC | ||
| 9/24/2022 | Miami-Ohio | 17 | at | Northwestern (1-11) | 14 | at B10 | ||
| 10/1/2022 | Miami-Ohio | 20 | at | Buffalo (7-6,5-3) | 24 | |||
| 10/8/2022 | Kent State (5-7,4-4) | 24 | at | Miami-Ohio | 27 | |||
| 10/15/2022 | Miami-Ohio | 13 | at | Bowling Green (6-7,5-3) | 17 | |||
| 10/22/2022 | Western Michigan (5-7,4-4) | 16 | at | Miami-Ohio | 10 | |||
| 10/29/2022 | Miami-Ohio | 27 | at | Akron (2-10,1-7) | 9 | |||
| 11/8/2022 | Ohio (10-4,7-2) | 37 | at | Miami-Ohio | 21 | |||
| 11/16/2022 | Miami-Ohio | 29 | at | Northern Illinois (3-9,2-6) | 23 | |||
| 11/22/2022 | Ball State (5-7,3-5) | 17 | at | Miami-Ohio | 18 | |||
| 12/16/2022 | Miami-Ohio | 20 | vs | UAB (7-6) | 24 | Nassau BA | vs CUSA |
| vs Miami-Ohio | vs Other Opponents | Miami-Ohio compared to OOs | |
| Record: | 7-6 | 60-89 | |
| Points Scored: | 22.62 | 23.98 | 1.36 |
| Points Allowed: | 20.23 | 28.15 | -7.92 |
| Margin: | 2.39 | -4.17 | -6.56 |
| Total Points: | 42.85 | 52.13 | -9.28 |