| 9/3/2022 | SMU | 48 | at | North Texas (7-7) | 10 | at CUSA | ||
| 9/10/2022 | Lamar (1-10) | 16 | at | SMU | 45 | SLC (1AA) | ||
| 9/17/2022 | SMU | 27 | at | Maryland (8-5) | 34 | at B10 | ||
| 9/24/2022 | TCU (13-2) | 42 | at | SMU | 34 | B12 | ||
| 10/5/2022 | SMU | 19 | at | UCF (9-5,6-3) | 41 | |||
| 10/14/2022 | Navy (4-8,4-4) | 34 | at | SMU | 40 | |||
| 10/22/2022 | Cincinnati (9-4,6-2) | 29 | at | SMU | 27 | |||
| 10/29/2022 | SMU | 45 | at | Tulsa (5-7,3-5) | 34 | |||
| 11/5/2022 | Houston (8-5,5-3) | 63 | at | SMU | 77 | |||
| 11/12/2022 | SMU | 41 | at | South Florida (1-11,0-8) | 23 | |||
| 11/17/2022 | SMU | 24 | at | Tulane (12-2,8-1) | 59 | |||
| 11/26/2022 | Memphis (7-6,3-5) | 31 | at | SMU | 34 | |||
| 12/17/2022 | SMU | 23 | vs | BYU (8-5) | 24 | Albuquerque NM | vs Ind |
| vs SMU | vs Other Opponents | SMU compared to OOs | |
| Record: | 6-7 | 86-70 | |
| Points Scored: | 33.85 | 31.14 | -2.71 |
| Points Allowed: | 37.23 | 27.84 | 9.39 |
| Margin: | -3.38 | 3.30 | 6.68 |
| Total Points: | 71.08 | 58.98 | 12.10 |