| 9/3/2022 | South Dakota State | 3 | at | Iowa (8-5) | 7 | at B10 | ||
| 9/10/2022 | UC Davis (6-5) | 22 | at | South Dakota State | 24 | BSky | ||
| 9/17/2022 | Butler (7-4) | 17 | at | South Dakota State | 45 | Pio | ||
| 9/24/2022 | South Dakota State | 28 | at | Missouri State (5-6,3-5) | 14 | |||
| 10/1/2022 | Western Illinois (0-11,0-8) | 10 | at | South Dakota State | 34 | |||
| 10/8/2022 | South Dakota (3-8,2-6) | 3 | at | South Dakota State | 28 | |||
| 10/15/2022 | South Dakota State | 23 | at | North Dakota State (12-3,7-2) | 21 | |||
| 10/22/2022 | South Dakota State | 49 | at | North Dakota (7-5,5-3) | 35 | |||
| 10/29/2022 | Indiana State (2-9,1-7) | 7 | at | South Dakota State | 49 | |||
| 11/5/2022 | South Dakota State | 31 | at | Northern Iowa (6-5,5-3) | 28 | |||
| 11/12/2022 | Illinois State (6-5,4-4) | 7 | at | South Dakota State | 31 | |||
| 12/3/2022 | Delaware (8-5) | 6 | at | South Dakota State | 42 | FCS Playoffs Round 2 | CAAF | |
| 12/10/2022 | Holy Cross (12-1) | 21 | at | South Dakota State | 42 | FCS Quarterful | Pat | |
| 12/17/2022 | Montana State (12-2) | 18 | at | South Dakota State | 39 | FCS Semifinal | BSky | |
| 1/8/2023 | North Dakota State (12-3,7-2) | 21 | vs | South Dakota State | 45 | Frisco TX - FCS Championship |
| vs South Dakota State | vs Other Opponents | South Dakota State compared to OOs | |
| Record: | 1-14 | 105-61 | |
| Points Scored: | 15.80 | 29.48 | 13.68 |
| Points Allowed: | 34.20 | 23.63 | 10.57 |
| Margin: | -18.40 | 5.85 | 24.25 |
| Total Points: | 50.00 | 53.11 | -3.11 |