| 8/27/2022 | Austin Peay (7-4) | 27 | at | Western Kentucky | 38 | ASUN (1AA) | ||
| 9/3/2022 | Western Kentucky | 49 | at | Hawaii (3-10) | 17 | at MW | ||
| 9/17/2022 | Western Kentucky | 30 | at | Indiana (4-8) | 33 | at B10 | ||
| 9/24/2022 | Florida Intl (4-8,2-6) | 0 | at | Western Kentucky | 73 | |||
| 10/1/2022 | Troy (12-2) | 34 | at | Western Kentucky | 27 | SBC | ||
| 10/8/2022 | Western Kentucky | 28 | at | Texas-San Antonio (11-3,9-0) | 31 | |||
| 10/15/2022 | Western Kentucky | 35 | at | Middle Tenn State (8-5,4-4) | 17 | |||
| 10/21/2022 | UAB (7-6,4-4) | 17 | at | Western Kentucky | 20 | |||
| 10/29/2022 | North Texas (7-7,6-3) | 40 | at | Western Kentucky | 13 | |||
| 11/5/2022 | Western Kentucky | 59 | at | UNC-Charlotte (3-9,2-6) | 7 | |||
| 11/12/2022 | Rice (5-8,3-5) | 10 | at | Western Kentucky | 45 | |||
| 11/19/2022 | Western Kentucky | 17 | at | Auburn (5-7) | 41 | at SEC | ||
| 11/26/2022 | Western Kentucky | 32 | at | Florida Atlantic (5-7,4-4) | 31 | OT | ||
| 12/21/2022 | Western Kentucky | 44 | vs | South Alabama (10-3) | 23 | New Orleans LA | vs SBC |
| vs Western Kentucky | vs Other Opponents | Western Kentucky compared to OOs | |
| Record: | 5-9 | 86-78 | |
| Points Scored: | 23.43 | 27.88 | 4.45 |
| Points Allowed: | 36.43 | 28.17 | 8.26 |
| Margin: | -13.00 | -0.29 | 12.71 |
| Total Points: | 59.86 | 56.05 | 3.81 |