| 8/27/2022 | Duquesne | 7 | at | Florida State | 47 | NE (1AA) | ||
| Florida A&M | 24 | at | North Carolina | 56 | SWAC (1AA) | |||
| 9/1/2022 | West Virginia | 31 | at | Pittsburgh | 38 | B12 | ||
| VMI | 10 | at | Wake Forest | 44 | SoCon (1AA) | |||
| 9/2/2022 | Temple | 0 | at | Duke | 30 | AAC | ||
| Virginia Tech | 17 | at | Old Dominion | 20 | @ SBC | |||
| 9/3/2022 | North Carolina | 63 | at | Appalachian State | 61 | @ SBC | ||
| Rutgers | 22 | at | Boston College | 21 | B10 | |||
| North Carolina State | 21 | at | East Carolina | 20 | @ AAC | |||
| Bethune-Cookman | 13 | at | Miami-Florida | 70 | SWAC (1AA) | |||
| Louisville | 7 | at | Syracuse | 31 | ||||
| Richmond | 17 | at | Virginia | 34 | CAAF (1AA) | |||
| 9/4/2022 | Florida State | 24 | vs | LSU | 23 | New Orleans LA | vs SEC | |
| 9/5/2022 | Clemson | 41 | at | Georgia Tech | 10 | |||
| 9/9/2022 | Louisville | 20 | at | UCF | 14 | @ AAC | ||
| 9/10/2022 | Furman | 12 | at | Clemson | 35 | SoCon (1AA) | ||
| Syracuse | 48 | at | Connecticut | 14 | @ Ind | |||
| North Carolina | 35 | at | Georgia State | 28 | @ SBC | |||
| Western Carolina | 17 | at | Georgia Tech | 35 | SoCon (1AA) | |||
| Virginia | 3 | at | Illinois | 24 | @ B10 | |||
| Southern Miss | 7 | at | Miami-Florida | 30 | SBC | |||
| Charleston Southern | 3 | at | North Carolina State | 55 | BigS (1AA) | |||
| Duke | 31 | at | Northwestern | 23 | @ B10 | |||
| Tennessee | 34 | at | Pittsburgh | 27 | OT | SEC | ||
| Wake Forest | 45 | at | Vanderbilt | 25 | @ SEC | |||
| Boston College | 10 | at | Virginia Tech | 27 | ||||
| 9/16/2022 | Florida State | 35 | at | Louisville | 31 | |||
| 9/17/2022 | Maine | 17 | at | Boston College | 38 | CAAF (1AA) | ||
| Louisiana Tech | 20 | at | Clemson | 48 | CUSA | |||
| North Carolina A&T | 20 | at | Duke | 49 | BigS (1AA) | |||
| Mississippi | 42 | at | Georgia Tech | 0 | SEC | |||
| Texas Tech | 14 | at | North Carolina State | 27 | B12 | |||
| Purdue | 29 | at | Syracuse | 32 | B10 | |||
| Miami-Florida | 9 | at | Texas A&M | 17 | @ SEC | |||
| Old Dominion | 14 | at | Virginia | 16 | SBC | |||
| Wofford | 7 | at | Virginia Tech | 27 | SoCon (1AA) | |||
| Liberty | 36 | at | Wake Forest | 37 | Ind | |||
| Pittsburgh | 34 | at | Western Michigan | 13 | @ MAC | |||
| 9/22/2022 | West Virginia | 33 | at | Virginia Tech | 10 | B12 | ||
| 9/23/2022 | Virginia | 20 | at | Syracuse | 22 | |||
| 9/24/2022 | Georgia Tech | 10 | at | UCF | 27 | @ AAC | ||
| Boston College | 14 | at | Florida State | 44 | ||||
| Duke | 27 | at | Kansas | 35 | @ B12 | |||
| South Florida | 3 | at | Louisville | 41 | AAC | |||
| Middle Tenn State | 45 | at | Miami-Florida | 31 | CUSA | |||
| Notre Dame | 45 | at | North Carolina | 32 | ND | |||
| Connecticut | 10 | at | North Carolina State | 41 | Ind | |||
| Rhode Island | 24 | at | Pittsburgh | 45 | CAAF (1AA) | |||
| Clemson | 51 | at | Wake Forest | 45 | ||||
| 10/1/2022 | Louisville | 33 | at | Boston College | 34 | |||
| North Carolina State | 20 | at | Clemson | 30 | ||||
| Virginia | 17 | at | Duke | 38 | ||||
| Wake Forest | 31 | at | Florida State | 21 | ||||
| Virginia Tech | 10 | at | North Carolina | 41 | ||||
| Georgia Tech | 26 | at | Pittsburgh | 21 | ||||
| Wagner | 0 | at | Syracuse | 59 | NE (1AA) | |||
| 10/8/2022 | Clemson | 31 | at | Boston College | 3 | |||
| Duke | 20 | at | Georgia Tech | 23 | OT | |||
| North Carolina | 27 | at | Miami-Florida | 24 | ||||
| Florida State | 17 | at | North Carolina State | 19 | ||||
| Virginia Tech | 29 | at | Pittsburgh | 45 | ||||
| Louisville | 34 | at | Virginia | 17 | ||||
| Army | 10 | at | Wake Forest | 45 | Ind | |||
| 10/15/2022 | North Carolina | 38 | at | Duke | 35 | |||
| Clemson | 34 | at | Florida State | 28 | ||||
| North Carolina State | 9 | at | Syracuse | 24 | ||||
| Miami-Florida | 20 | at | Virginia Tech | 14 | ||||
| 10/20/2022 | Virginia | 16 | at | Georgia Tech | 9 | |||
| 10/22/2022 | Syracuse | 21 | at | Clemson | 27 | |||
| Pittsburgh | 10 | at | Louisville | 24 | ||||
| Duke | 45 | at | Miami-Florida | 21 | ||||
| Boston College | 15 | at | Wake Forest | 43 | ||||
| 10/27/2022 | Virginia Tech | 21 | at | North Carolina State | 22 | |||
| 10/29/2022 | Boston College | 3 | at | Connecticut | 13 | @ Ind | ||
| Georgia Tech | 16 | at | Florida State | 41 | ||||
| Wake Forest | 21 | at | Louisville | 48 | ||||
| Pittsburgh | 24 | at | North Carolina | 42 | ||||
| Notre Dame | 41 | at | Syracuse | 24 | ND | |||
| Miami-Florida | 14 | at | Virginia | 12 | 4OT | |||
| 11/4/2022 | Duke | 38 | at | Boston College | 31 | |||
| 11/5/2022 | James Madison | 10 | at | Louisville | 34 | SBC | ||
| Florida State | 45 | at | Miami-Florida | 3 | ||||
| Wake Forest | 21 | at | North Carolina State | 30 | ||||
| Clemson | 14 | at | Notre Dame | 35 | @ ND | |||
| Syracuse | 9 | at | Pittsburgh | 19 | ||||
| North Carolina | 31 | at | Virginia | 28 | ||||
| Georgia Tech | 28 | at | Virginia Tech | 27 | ||||
| 11/12/2022 | Louisville | 16 | at | Clemson | 31 | |||
| Virginia Tech | 7 | at | Duke | 24 | ||||
| Miami-Florida | 35 | at | Georgia Tech | 14 | ||||
| Boston College | 21 | at | North Carolina State | 20 | ||||
| Florida State | 38 | at | Syracuse | 3 | ||||
| Pittsburgh | 37 | at | Virginia | 7 | ||||
| North Carolina | 36 | at | Wake Forest | 34 | ||||
| 11/19/2022 | Miami-Florida | 10 | at | Clemson | 40 | |||
| UL Lafayette | 17 | at | Florida State | 49 | SBC | |||
| Virginia Tech | 23 | at | Liberty | 22 | @ Ind | |||
| North Carolina State | 10 | at | Louisville | 25 | ||||
| Georgia Tech | 21 | at | North Carolina | 17 | ||||
| Boston College | 0 | at | Notre Dame | 44 | @ ND | |||
| Duke | 26 | at | Pittsburgh | 28 | ||||
| Coastal Carolina | vs | Virginia | Cancelled shooting | vs SBC | ||||
| Syracuse | 35 | at | Wake Forest | 45 | ||||
| 11/25/2022 | Florida | 38 | at | Florida State | 45 | SEC | ||
| North Carolina State | 30 | at | North Carolina | 27 | 2OT | |||
| Virginia | at | Virginia Tech | Cancelled | |||||
| 11/26/2022 | Syracuse | 32 | at | Boston College | 23 | |||
| South Carolina | 31 | at | Clemson | 30 | SEC | |||
| Wake Forest | 31 | at | Duke | 34 | ||||
| Georgia Tech | 14 | at | Georgia | 37 | @ SEC | |||
| Louisville | 13 | at | Kentucky | 26 | @ SEC | |||
| Pittsburgh | 42 | at | Miami-Florida | 16 | ||||
| 12/3/2022 | Clemson | 39 | vs | North Carolina | 10 | ACC Championship Charlotte NC | ||
| 12/17/2022 | Cincinnati | 7 | vs | Louisville | 24 | Boston MA | vs AAC | |
| 12/23/2022 | Wake Forest | 27 | vs | Missouri | 17 | Tampa FL | vs SEC | |
| 12/28/2022 | UCF | 13 | vs | Duke | 30 | Annapolis MD | vs AAC | |
| Oregon | 28 | vs | North Carolina | 27 | San Diego CA | vs P12 | ||
| 12/29/2022 | Oklahoma | 32 | vs | Florida State | 35 | Orlando FL | vs B12 | |
| Syracuse | 20 | vs | Minnesota | 28 | Bronx NY | vs B10 | ||
| 12/30/2022 | Tennessee | 31 | vs | Clemson | 14 | Miami Gardens FL | vs SEC | |
| Maryland | 16 | vs | North Carolina State | 12 | Charlotte NC | vs B10 | ||
| Pittsburgh | 37 | vs | UCLA | 35 | El Paso TX | vs P12 |