| 9/3/2022 | Bethune-Cookman | 13 | at | Miami-Florida (5-7) | 70 | at ACC | ||
| 9/10/2022 | South Carolina State (3-8) | 33 | at | Bethune-Cookman | 9 | MEAC | ||
| 9/24/2022 | Grambling (3-8,2-7) | 19 | at | Bethune-Cookman | 36 | |||
| 10/1/2022 | Bethune-Cookman | 27 | at | Alabama A&M (4-7,4-4) | 35 | |||
| 10/8/2022 | Bethune-Cookman | 17 | at | Tennessee State (4-7) | 41 | at OVC | ||
| 10/15/2022 | Jackson State (12-1,10-0) | 48 | vs | Bethune-Cookman | 8 | Jacksonville FL | ||
| 10/22/2022 | Bethune-Cookman | 45 | at | Mississippi Valley State (2-9,2-6) | 35 | |||
| 10/29/2022 | Bethune-Cookman | 48 | at | Prairie View (6-5,5-3) | 58 | |||
| 11/5/2022 | Alabama State (6-5,4-4) | 37 | at | Bethune-Cookman | 22 | |||
| 11/12/2022 | Bethune-Cookman | 14 | at | Alcorn State (5-6,4-4) | 17 | |||
| 11/19/2022 | Florida A&M (9-2,7-1) | 41 | vs | Bethune-Cookman | 20 | Orlando FL |
| vs Bethune-Cookman | vs Other Opponents | Bethune-Cookman compared to OOs | |
| Record: | 9-2 | 50-63 | |
| Points Scored: | 39.45 | 21.80 | -17.65 |
| Points Allowed: | 23.55 | 25.95 | -2.40 |
| Margin: | 15.90 | -4.15 | -20.05 |
| Total Points: | 63.00 | 47.75 | 15.25 |