| 9/3/2022 | North Carolina A&T | 13 | vs | North Carolina Central (10-2) | 28 | Charlotte NC | vs MEAC | |
| 9/10/2022 | North Carolina A&T | 3 | at | North Dakota State (12-3) | 43 | at MVC | ||
| 9/17/2022 | North Carolina A&T | 20 | at | Duke (9-4) | 49 | at ACC | ||
| 9/24/2022 | South Carolina State (3-8) | 27 | at | North Carolina A&T | 41 | MEAC | ||
| 10/1/2022 | Bryant (4-7,2-3) | 13 | at | North Carolina A&T | 24 | |||
| 10/15/2022 | Edward Waters (4-6) | 7 | at | North Carolina A&T | 45 | SIAC (D2) | ||
| 10/22/2022 | North Carolina A&T | 38 | at | Robert Morris (0-11,0-5) | 14 | |||
| 10/29/2022 | Campbell (5-6,2-3) | 38 | at | North Carolina A&T | 45 | |||
| 11/5/2022 | Norfolk State (2-9) | 24 | at | North Carolina A&T | 49 | MEAC | ||
| 11/12/2022 | Charleston Southern (2-8,2-3) | 10 | at | North Carolina A&T | 20 | |||
| 11/19/2022 | North Carolina A&T | 17 | at | Gardner-Webb (7-6,5-0) | 38 |
| vs North Carolina A&T | vs Other Opponents | North Carolina A&T compared to OOs | |
| Record: | 4-7 | 54-63 | |
| Points Scored: | 26.45 | 27.89 | 1.44 |
| Points Allowed: | 28.64 | 28.44 | 0.20 |
| Margin: | -2.19 | -0.55 | 1.64 |
| Total Points: | 55.09 | 56.33 | -1.24 |