| 9/3/2022 | Liberty (8-5) | 29 | at | Southern Miss | 27 | 4OT | Ind | |
| 9/10/2022 | Southern Miss | 7 | at | Miami-Florida (5-7) | 30 | at ACC | ||
| 9/17/2022 | Northwestern State (4-7) | 10 | at | Southern Miss | 64 | SLC (1AA) | ||
| 9/24/2022 | Southern Miss | 27 | at | Tulane (12-2) | 24 | at AAC | ||
| 10/8/2022 | Southern Miss | 10 | at | Troy (12-2,8-1) | 27 | |||
| 10/15/2022 | Arkansas State (3-9,1-7) | 19 | at | Southern Miss | 20 | |||
| 10/22/2022 | Southern Miss | 20 | at | Texas State (4-8,2-6) | 14 | |||
| 10/27/2022 | UL Lafayette (6-7,4-4) | 24 | at | Southern Miss | 39 | |||
| 11/5/2022 | Georgia State (4-8,3-5) | 42 | at | Southern Miss | 14 | |||
| 11/12/2022 | Southern Miss | 23 | at | Coastal Carolina (9-4,6-3) | 26 | |||
| 11/19/2022 | South Alabama (10-3,7-1) | 27 | at | Southern Miss | 20 | |||
| 11/26/2022 | Southern Miss | 20 | at | UL Monroe (4-8,3-5) | 10 | |||
| 12/17/2022 | Rice (5-8) | 24 | vs | Southern Miss | 38 | Mobile AL | CUSA |
| vs Southern Miss | vs Other Opponents | Southern Miss compared to OOs | |
| Record: | 6-7 | 80-71 | |
| Points Scored: | 23.54 | 26.93 | 3.39 |
| Points Allowed: | 25.31 | 27.76 | -2.45 |
| Margin: | -1.77 | -0.83 | 0.94 |
| Total Points: | 48.85 | 54.69 | -5.84 |