| 9/1/2022 | North Greenville (3-8) | 0 | at | Furman | 52 | GSC (D2) | ||
| 9/10/2022 | Furman | 12 | at | Clemson (11-3) | 35 | at ACC | ||
| 9/17/2022 | Furman | 27 | at | East Tennessee St (3-8,1-7) | 14 | |||
| 9/24/2022 | Furman | 24 | at | Charleston Southern (2-8) | 19 | at BigS | ||
| 10/1/2022 | Samford (11-2,8-0) | 34 | at | Furman | 27 | |||
| 10/8/2022 | Furman | 21 | at | The Citadel (4-7,3-5) | 10 | |||
| 10/15/2022 | Western Carolina (6-5,4-4) | 40 | at | Furman | 47 | |||
| 10/22/2022 | Furman | 41 | at | VMI (1-10,0-8) | 3 | |||
| 10/29/2022 | Chattanooga (7-4,5-3) | 20 | at | Furman | 24 | |||
| 11/12/2022 | Furman | 23 | at | Mercer (7-4,5-3) | 13 | |||
| 11/19/2022 | Wofford (3-8,3-5) | 28 | at | Furman | 63 | |||
| 11/26/2022 | Elon (8-4) | 6 | at | Furman | 31 | FCS Championship - Round 1 | CAAF | |
| 12/3/2022 | Furman | 38 | at | Incarnate Word (12-2) | 41 | FCS Playoffs Round 2 | at SLC |
| vs Furman | vs Other Opponents | Furman compared to OOs | |
| Record: | 3-10 | 75-63 | |
| Points Scored: | 20.23 | 30.29 | 10.06 |
| Points Allowed: | 33.08 | 26.92 | 6.16 |
| Margin: | -12.85 | 3.37 | 16.22 |
| Total Points: | 53.31 | 57.21 | -3.90 |