| 9/3/2022 | Troy (12-2) | 10 | at | Mississippi | 28 | SBC | ||
| 9/10/2022 | Central Arkansas (5-6) | 3 | at | Mississippi | 59 | ASUN (1AA) | ||
| 9/17/2022 | Mississippi | 42 | at | Georgia Tech (5-7) | 0 | at ACC | ||
| 9/24/2022 | Tulsa (5-7) | 27 | at | Mississippi | 35 | AAC | ||
| 10/1/2022 | Kentucky (7-6,3-5) | 19 | at | Mississippi | 22 | |||
| 10/8/2022 | Mississippi | 52 | at | Vanderbilt (5-7,2-6) | 28 | |||
| 10/15/2022 | Auburn (5-7,2-6) | 34 | at | Mississippi | 48 | |||
| 10/22/2022 | Mississippi | 20 | at | LSU (10-4,6-3) | 45 | |||
| 10/29/2022 | Mississippi | 31 | at | Texas A&M (5-7,2-6) | 28 | |||
| 11/12/2022 | Alabama (11-2,6-2) | 30 | at | Mississippi | 24 | |||
| 11/19/2022 | Mississippi | 27 | at | Arkansas (7-6,3-5) | 42 | |||
| 11/24/2022 | Mississippi State (9-4,4-4) | 24 | at | Mississippi | 22 | |||
| 12/28/2022 | Texas Tech (8-5) | 42 | vs | Mississippi | 25 | Houston TX | B12 |
| vs Mississippi | vs Other Opponents | Mississippi compared to OOs | |
| Record: | 5-8 | 89-62 | |
| Points Scored: | 25.54 | 28.99 | 3.45 |
| Points Allowed: | 33.46 | 25.25 | 8.21 |
| Margin: | -7.92 | 3.74 | 11.66 |
| Total Points: | 59.00 | 54.24 | 4.76 |