| 8/27/2022 | Nebraska (4-8,3-6) | 28 | vs | Northwestern | 31 | Dublin IE | ||
| 9/10/2022 | Duke (9-4) | 31 | at | Northwestern | 23 | ACC | ||
| 9/17/2022 | Southern Illinois (5-6) | 31 | at | Northwestern | 24 | MVC (1AA) | ||
| 9/24/2022 | Miami-Ohio (6-7) | 17 | at | Northwestern | 14 | MAC | ||
| 10/1/2022 | Northwestern | 7 | at | Penn State (11-2,7-2) | 17 | |||
| 10/8/2022 | Wisconsin (7-6,4-5) | 42 | at | Northwestern | 7 | |||
| 10/22/2022 | Northwestern | 24 | at | Maryland (8-5,4-5) | 31 | |||
| 10/29/2022 | Northwestern | 13 | at | Iowa (8-5,5-4) | 33 | |||
| 11/5/2022 | Ohio State (11-2,8-1) | 21 | at | Northwestern | 7 | |||
| 11/12/2022 | Northwestern | 3 | at | Minnesota (9-4,5-4) | 31 | |||
| 11/19/2022 | Northwestern | 9 | at | Purdue (8-6,6-4) | 17 | |||
| 11/26/2022 | Illinois (8-5,5-4) | 41 | at | Northwestern | 3 |
| vs Northwestern | vs Other Opponents | Northwestern compared to OOs | |
| Record: | 11-1 | 83-59 | |
| Points Scored: | 28.33 | 27.92 | -0.41 |
| Points Allowed: | 13.75 | 21.25 | -7.50 |
| Margin: | 14.58 | 6.67 | -7.91 |
| Total Points: | 42.08 | 49.17 | -7.09 |