| 9/1/2022 | Ball State (5-7) | 10 | at | Tennessee | 59 | MAC | ||
| 9/10/2022 | Tennessee | 34 | at | Pittsburgh (9-4) | 27 | OT | at ACC | |
| 9/17/2022 | Akron (2-10) | 6 | at | Tennessee | 63 | MAC | ||
| 9/24/2022 | Florida (6-7,3-5) | 33 | at | Tennessee | 38 | |||
| 10/8/2022 | Tennessee | 40 | at | LSU (10-4,6-3) | 13 | |||
| 10/15/2022 | Alabama (11-2,6-2) | 49 | at | Tennessee | 52 | |||
| 10/22/2022 | Tennessee-Martin (7-4) | 24 | at | Tennessee | 65 | OVC (1AA) | ||
| 10/29/2022 | Kentucky (7-6,3-5) | 6 | at | Tennessee | 44 | |||
| 11/5/2022 | Tennessee | 13 | at | Georgia (15-0,9-0) | 27 | |||
| 11/12/2022 | Missouri (6-7,3-5) | 24 | at | Tennessee | 66 | |||
| 11/19/2022 | Tennessee | 38 | at | South Carolina (8-5,4-4) | 63 | |||
| 11/26/2022 | Tennessee | 56 | at | Vanderbilt (5-7,2-6) | 0 | |||
| 12/30/2022 | Tennessee | 31 | vs | Clemson (11-3) | 14 | Miami Gardens FL | vs ACC |
| vs Tennessee | vs Other Opponents | Tennessee compared to OOs | |
| Record: | 2-11 | 100-55 | |
| Points Scored: | 22.77 | 31.07 | 8.30 |
| Points Allowed: | 46.08 | 23.15 | 22.93 |
| Margin: | -23.31 | 7.92 | 31.23 |
| Total Points: | 68.85 | 54.22 | 14.63 |