| 9/3/2022 | Georgia State (4-8) | 14 | at | South Carolina | 35 | SBC | ||
| 9/10/2022 | South Carolina | 30 | at | Arkansas (7-6,3-5) | 44 | |||
| 9/17/2022 | Georgia (15-0,9-0) | 48 | at | South Carolina | 7 | |||
| 9/24/2022 | UNC-Charlotte (3-9) | 20 | at | South Carolina | 56 | CUSA | ||
| 9/29/2022 | South Carolina State (3-8) | 10 | at | South Carolina | 50 | MEAC (1AA) | ||
| 10/8/2022 | South Carolina | 24 | at | Kentucky (7-6,3-5) | 14 | |||
| 10/22/2022 | Texas A&M (5-7,2-6) | 24 | at | South Carolina | 30 | |||
| 10/29/2022 | Missouri (6-7,3-5) | 23 | at | South Carolina | 10 | |||
| 11/5/2022 | South Carolina | 38 | at | Vanderbilt (5-7,2-6) | 27 | |||
| 11/12/2022 | South Carolina | 6 | at | Florida (6-7,3-5) | 38 | |||
| 11/19/2022 | Tennessee (11-2,6-2) | 38 | at | South Carolina | 63 | |||
| 11/26/2022 | South Carolina | 31 | at | Clemson (11-3) | 30 | at ACC | ||
| 12/30/2022 | Notre Dame (9-4) | 45 | vs | South Carolina | 38 | Jacksonville FL | ND |
| vs South Carolina | vs Other Opponents | South Carolina compared to OOs | |
| Record: | 5-8 | 87-66 | |
| Points Scored: | 28.85 | 29.93 | 1.08 |
| Points Allowed: | 32.15 | 25.52 | 6.63 |
| Margin: | -3.30 | 4.41 | 7.71 |
| Total Points: | 61.00 | 55.45 | 5.55 |