| 9/3/2022 | North Carolina (9-5) | 63 | at | Appalachian State | 61 | ACC | ||
| 9/10/2022 | Appalachian State | 17 | at | Texas A&M (5-7) | 14 | at SEC | ||
| 9/17/2022 | Troy (12-2,8-1) | 28 | at | Appalachian State | 32 | |||
| 9/24/2022 | James Madison (8-3,6-2) | 32 | at | Appalachian State | 28 | |||
| 10/1/2022 | The Citadel (4-7) | 0 | at | Appalachian State | 49 | SoCon (1AA) | ||
| 10/8/2022 | Appalachian State | 24 | at | Texas State (4-8,2-6) | 36 | |||
| 10/19/2022 | Georgia State (4-8,3-5) | 17 | at | Appalachian State | 42 | |||
| 10/29/2022 | Robert Morris (0-11) | 3 | at | Appalachian State | 42 | BigS (1AA) | ||
| 11/3/2022 | Appalachian State | 28 | at | Coastal Carolina (9-4,6-3) | 35 | |||
| 11/12/2022 | Appalachian State | 21 | at | Marshall (9-4,5-3) | 28 | |||
| 11/19/2022 | Old Dominion (3-9,2-6) | 14 | at | Appalachian State | 27 | |||
| 11/26/2022 | Appalachian State | 48 | at | Georgia Southern (6-7,3-5) | 51 | 2OT |
| vs Appalachian State | vs Other Opponents | Appalachian State compared to OOs | |
| Record: | 6-6 | 67-69 | |
| Points Scored: | 26.75 | 25.60 | -1.15 |
| Points Allowed: | 34.92 | 25.23 | 9.69 |
| Margin: | -8.17 | 0.37 | 8.54 |
| Total Points: | 61.67 | 50.83 | 10.84 |