| 8/27/2022 | Wyoming (7-6) | 6 | at | Illinois | 38 | MW | ||
| 9/2/2022 | Illinois | 20 | at | Indiana (4-8,2-7) | 23 | |||
| 9/10/2022 | Virginia (3-7) | 3 | at | Illinois | 24 | ACC | ||
| 9/22/2022 | Chattanooga (7-4) | 0 | at | Illinois | 31 | SoCon (1AA) | ||
| 10/1/2022 | Illinois | 34 | at | Wisconsin (7-6,4-5) | 10 | |||
| 10/8/2022 | Iowa (8-5,5-4) | 6 | at | Illinois | 9 | |||
| 10/15/2022 | Minnesota (9-4,5-4) | 14 | at | Illinois | 26 | |||
| 10/29/2022 | Illinois | 26 | at | Nebraska (4-8,3-6) | 9 | |||
| 11/5/2022 | Michigan State (5-7,3-6) | 23 | at | Illinois | 15 | |||
| 11/12/2022 | Purdue (8-6,6-4) | 31 | at | Illinois | 24 | |||
| 11/19/2022 | Illinois | 17 | at | Michigan (13-1,10-0) | 19 | |||
| 11/26/2022 | Illinois | 41 | at | Northwestern (1-11,1-8) | 3 | |||
| 1/2/2023 | Mississippi State (9-4) | 19 | vs | Illinois | 10 | Tampa FL | SEC |
| vs Illinois | vs Other Opponents | Illinois compared to OOs | |
| Record: | 5-8 | 80-69 | |
| Points Scored: | 12.77 | 26.15 | 13.38 |
| Points Allowed: | 24.23 | 22.78 | 1.45 |
| Margin: | -11.46 | 3.37 | 14.83 |
| Total Points: | 37.00 | 48.93 | -11.93 |