| 8/27/2022 | Duquesne | 7 | at | Florida State (10-3) | 47 | at ACC | ||
| 9/3/2022 | Duquesne | 14 | at | Youngstown State (7-4) | 31 | at MVC | ||
| 9/10/2022 | Thomas More (5-6) | 14 | at | Duquesne | 34 | MSC (NAIA) | ||
| 9/17/2022 | Duquesne | 14 | at | Hawaii (3-10) | 24 | at MW | ||
| 10/1/2022 | Duquesne | 20 | at | Stonehill (4-5,2-5) | 24 | |||
| 10/8/2022 | Merrimack (8-3,6-1) | 28 | at | Duquesne | 21 | |||
| 10/22/2022 | Duquesne | 30 | at | Central Conn (2-9,2-5) | 6 | |||
| 10/29/2022 | LIU (4-7,4-3) | 50 | at | Duquesne | 48 | 2OT | ||
| 11/5/2022 | Sacred Heart (5-6,3-4) | 28 | at | Duquesne | 35 | |||
| 11/12/2022 | Duquesne | 14 | at | St Francis PA (9-3,7-0) | 51 | |||
| 11/19/2022 | Wagner (1-10,1-6) | 0 | at | Duquesne | 33 |
| vs Duquesne | vs Other Opponents | Duquesne compared to OOs | |
| Record: | 7-4 | 51-62 | |
| Points Scored: | 27.55 | 25.46 | -2.09 |
| Points Allowed: | 24.55 | 28.66 | -4.11 |
| Margin: | 3.00 | -3.20 | -6.20 |
| Total Points: | 52.10 | 54.12 | -2.02 |