| 9/3/2022 | Western Carolina (6-5) | 52 | at | Charleston Southern | 38 | SoCon | ||
| 9/10/2022 | Charleston Southern | 3 | at | North Carolina State (8-5) | 55 | at ACC | ||
| 9/17/2022 | Charleston Southern | 17 | at | Eastern Kentucky (7-5) | 40 | at ASUN | ||
| 9/24/2022 | Furman (10-3) | 24 | at | Charleston Southern | 19 | SoCon | ||
| 10/8/2022 | Charleston Southern | 28 | at | Campbell (5-6,2-3) | 34 | |||
| 10/15/2022 | Charleston Southern | 24 | at | Bryant (4-7,2-3) | 23 | |||
| 10/22/2022 | Gardner-Webb (7-6,5-0) | 28 | at | Charleston Southern | 14 | |||
| 10/29/2022 | Charleston Southern | 20 | at | Kennesaw St (5-6) | 30 | at ASUN | ||
| 11/5/2022 | Robert Morris (0-11,0-5) | 21 | at | Charleston Southern | 34 | |||
| 11/12/2022 | Charleston Southern | 10 | at | North Carolina A&T (7-4,4-1) | 20 |
| vs Charleston Southern | vs Other Opponents | Charleston Southern compared to OOs | |
| Record: | 8-2 | 51-56 | |
| Points Scored: | 32.70 | 28.55 | -4.15 |
| Points Allowed: | 20.70 | 29.44 | -8.74 |
| Margin: | 12.00 | -0.89 | -12.89 |
| Total Points: | 53.40 | 57.99 | -4.59 |