| 9/3/2022 | Southeastern Louisiana (9-4) | 7 | at | UL Lafayette | 24 | SLC (1AA) | ||
| 9/10/2022 | Eastern Michigan (9-4) | 21 | at | UL Lafayette | 49 | MAC | ||
| 9/17/2022 | UL Lafayette | 21 | at | Rice (5-8) | 33 | at CUSA | ||
| 9/24/2022 | UL Lafayette | 17 | at | UL Monroe (4-8,3-5) | 21 | |||
| 10/1/2022 | South Alabama (10-3,7-1) | 20 | at | UL Lafayette | 17 | |||
| 10/12/2022 | UL Lafayette | 23 | at | Marshall (9-4,5-3) | 13 | |||
| 10/22/2022 | Arkansas State (3-9,1-7) | 18 | at | UL Lafayette | 38 | |||
| 10/27/2022 | UL Lafayette | 24 | at | Southern Miss (7-6,4-4) | 39 | |||
| 11/5/2022 | Troy (12-2,8-1) | 23 | at | UL Lafayette | 17 | |||
| 11/10/2022 | Georgia Southern (6-7,3-5) | 17 | at | UL Lafayette | 36 | |||
| 11/19/2022 | UL Lafayette | 17 | at | Florida State (10-3) | 49 | at ACC | ||
| 11/26/2022 | UL Lafayette | 41 | at | Texas State (4-8,2-6) | 13 | |||
| 12/23/2022 | UL Lafayette | 16 | vs | Houston (8-5) | 23 | Shreveport LA | vs AAC |
| vs UL Lafayette | vs Other Opponents | UL Lafayette compared to OOs | |
| Record: | 7-6 | 89-65 | |
| Points Scored: | 22.85 | 29.04 | 6.19 |
| Points Allowed: | 26.15 | 26.27 | -0.12 |
| Margin: | -3.30 | 2.77 | 6.07 |
| Total Points: | 49.00 | 55.31 | -6.31 |