| 9/3/2022 | Middle Tenn State (8-5) | 7 | at | James Madison | 44 | CUSA | ||
| 9/10/2022 | Norfolk State (2-9) | 7 | at | James Madison | 63 | MEAC (1AA) | ||
| 9/24/2022 | James Madison | 32 | at | Appalachian State (6-6,3-5) | 28 | |||
| 10/1/2022 | Texas State (4-8,2-6) | 13 | at | James Madison | 40 | |||
| 10/8/2022 | James Madison | 42 | at | Arkansas State (3-9,1-7) | 20 | |||
| 10/15/2022 | James Madison | 38 | at | Georgia Southern (6-7,3-5) | 45 | |||
| 10/22/2022 | Marshall (9-4,5-3) | 26 | at | James Madison | 12 | |||
| 11/5/2022 | James Madison | 10 | at | Louisville (8-5) | 34 | at ACC | ||
| 11/12/2022 | James Madison | 37 | at | Old Dominion (3-9,2-6) | 3 | |||
| 11/19/2022 | Georgia State (4-8,3-5) | 40 | at | James Madison | 42 | |||
| 11/26/2022 | Coastal Carolina (9-4,6-3) | 7 | at | James Madison | 47 |
| vs James Madison | vs Other Opponents | James Madison compared to OOs | |
| Record: | 3-8 | 59-66 | |
| Points Scored: | 20.91 | 26.97 | 6.06 |
| Points Allowed: | 37.00 | 27.09 | 9.91 |
| Margin: | -16.09 | -0.12 | 15.97 |
| Total Points: | 57.91 | 54.06 | 3.85 |