| 8/27/2022 | Vanderbilt | 63 | at | Hawaii (3-10) | 10 | at MW | ||
| 9/3/2022 | Elon (8-4) | 31 | at | Vanderbilt | 42 | CAAF (1AA) | ||
| 9/10/2022 | Wake Forest (8-5) | 45 | at | Vanderbilt | 25 | ACC | ||
| 9/17/2022 | Vanderbilt | 38 | at | Northern Illinois (3-9) | 28 | at MAC | ||
| 9/24/2022 | Vanderbilt | 3 | at | Alabama (11-2,6-2) | 55 | |||
| 10/8/2022 | Mississippi (8-5,4-4) | 52 | at | Vanderbilt | 28 | |||
| 10/15/2022 | Vanderbilt | 0 | at | Georgia (15-0,9-0) | 55 | |||
| 10/22/2022 | Vanderbilt | 14 | at | Missouri (6-7,3-5) | 17 | |||
| 11/5/2022 | South Carolina (8-5,4-4) | 38 | at | Vanderbilt | 27 | |||
| 11/12/2022 | Vanderbilt | 24 | at | Kentucky (7-6,3-5) | 21 | |||
| 11/19/2022 | Florida (6-7,3-5) | 24 | at | Vanderbilt | 31 | |||
| 11/26/2022 | Tennessee (11-2,6-2) | 56 | at | Vanderbilt | 0 |
| vs Vanderbilt | vs Other Opponents | Vanderbilt compared to OOs | |
| Record: | 7-5 | 87-57 | |
| Points Scored: | 36.00 | 31.28 | -4.72 |
| Points Allowed: | 24.58 | 24.85 | -0.27 |
| Margin: | 11.42 | 6.43 | -4.99 |
| Total Points: | 60.58 | 56.13 | 4.45 |