| 9/2/2022 | Virginia Tech (3-8) | 17 | at | Old Dominion | 20 | ACC | ||
| 9/10/2022 | Old Dominion | 21 | at | East Carolina (8-5) | 39 | at AAC | ||
| 9/17/2022 | Old Dominion | 14 | at | Virginia (3-7) | 16 | at ACC | ||
| 9/24/2022 | Arkansas State (3-9,1-7) | 26 | at | Old Dominion | 29 | |||
| 10/1/2022 | Liberty (8-5) | 38 | at | Old Dominion | 24 | Ind | ||
| 10/15/2022 | Old Dominion | 49 | at | Coastal Carolina (9-4,6-3) | 21 | |||
| 10/22/2022 | Georgia Southern (6-7,3-5) | 28 | at | Old Dominion | 23 | |||
| 10/29/2022 | Old Dominion | 17 | at | Georgia State (4-8,3-5) | 31 | |||
| 11/5/2022 | Marshall (9-4,5-3) | 12 | at | Old Dominion | 0 | |||
| 11/12/2022 | James Madison (8-3,6-2) | 37 | at | Old Dominion | 3 | |||
| 11/19/2022 | Old Dominion | 14 | at | Appalachian State (6-6,3-5) | 27 | |||
| 11/26/2022 | Old Dominion | 20 | at | South Alabama (10-3,7-1) | 27 |
| vs Old Dominion | vs Other Opponents | Old Dominion compared to OOs | |
| Record: | 9-3 | 68-66 | |
| Points Scored: | 26.58 | 28.78 | 2.20 |
| Points Allowed: | 19.50 | 26.59 | -7.09 |
| Margin: | 7.08 | 2.19 | -4.89 |
| Total Points: | 46.08 | 55.37 | -9.29 |