| 9/1/2022 | Louisiana Tech (3-9) | 24 | at | Missouri | 52 | CUSA | ||
| 9/10/2022 | Missouri | 12 | at | Kansas State (10-4) | 40 | at B12 | ||
| 9/17/2022 | Abilene Christian (7-4) | 17 | at | Missouri | 34 | WAC (1AA) | ||
| 9/24/2022 | Missouri | 14 | at | Auburn (5-7,2-6) | 17 | OT | ||
| 10/1/2022 | Georgia (15-0,9-0) | 26 | at | Missouri | 22 | |||
| 10/8/2022 | Missouri | 17 | at | Florida (6-7,3-5) | 24 | |||
| 10/22/2022 | Vanderbilt (5-7,2-6) | 14 | at | Missouri | 17 | |||
| 10/29/2022 | Missouri | 23 | at | South Carolina (8-5,4-4) | 10 | |||
| 11/5/2022 | Kentucky (7-6,3-5) | 21 | at | Missouri | 17 | |||
| 11/12/2022 | Missouri | 24 | at | Tennessee (11-2,6-2) | 66 | |||
| 11/19/2022 | New Mexico State (7-6) | 14 | at | Missouri | 45 | Ind | ||
| 11/25/2022 | Arkansas (7-6,3-5) | 27 | at | Missouri | 29 | |||
| 12/23/2022 | Wake Forest (8-5) | 27 | vs | Missouri | 17 | Tampa FL | ACC |
| vs Missouri | vs Other Opponents | Missouri compared to OOs | |
| Record: | 7-6 | 92-62 | |
| Points Scored: | 25.15 | 31.69 | 6.54 |
| Points Allowed: | 24.85 | 26.34 | -1.49 |
| Margin: | 0.30 | 5.35 | 5.05 |
| Total Points: | 50.00 | 58.03 | -8.03 |