| 9/3/2022 | Liberty | 29 | at | Southern Miss (7-6) | 27 | 4OT | at SBC | |
| 9/10/2022 | UAB (7-6) | 14 | at | Liberty | 21 | CUSA | ||
| 9/17/2022 | Liberty | 36 | at | Wake Forest (8-5) | 37 | at ACC | ||
| 9/24/2022 | Akron (2-10) | 12 | at | Liberty | 21 | MAC | ||
| 10/1/2022 | Liberty | 38 | at | Old Dominion (3-9) | 24 | at SBC | ||
| 10/8/2022 | Liberty | 42 | at | Massachusetts (1-11,0-4) | 24 | |||
| 10/15/2022 | Gardner-Webb (7-6) | 20 | at | Liberty | 21 | BigS (1AA) | ||
| 10/22/2022 | BYU (8-5,0-1) | 14 | at | Liberty | 41 | |||
| 11/5/2022 | Liberty | 21 | at | Arkansas (7-6) | 19 | at SEC | ||
| 11/12/2022 | Liberty | 33 | at | Connecticut (6-7,2-1) | 36 | |||
| 11/19/2022 | Virginia Tech (3-8) | 23 | at | Liberty | 22 | ACC | ||
| 11/26/2022 | New Mexico State (7-6,2-0) | 49 | at | Liberty | 14 | |||
| 12/20/2022 | Liberty | 19 | vs | Toledo (9-5) | 21 | Boca Raton FL | vs MAC |
| vs Liberty | vs Other Opponents | Liberty compared to OOs | |
| Record: | 5-8 | 70-82 | |
| Points Scored: | 24.62 | 26.28 | 1.66 |
| Points Allowed: | 27.54 | 27.26 | 0.28 |
| Margin: | -2.92 | -0.98 | 1.94 |
| Total Points: | 52.16 | 53.54 | -1.38 |