| 9/3/2022 | BYU (8-5) | 50 | at | South Florida | 21 | Ind | ||
| 9/10/2022 | Howard (5-6) | 20 | at | South Florida | 42 | MEAC (1AA) | ||
| 9/17/2022 | South Florida | 28 | at | Florida (6-7) | 31 | at SEC | ||
| 9/24/2022 | South Florida | 3 | at | Louisville (8-5) | 41 | at ACC | ||
| 10/1/2022 | East Carolina (8-5,4-4) | 48 | at | South Florida | 28 | |||
| 10/8/2022 | South Florida | 24 | at | Cincinnati (9-4,6-2) | 28 | |||
| 10/15/2022 | Tulane (12-2,8-1) | 45 | at | South Florida | 31 | |||
| 10/29/2022 | South Florida | 27 | at | Houston (8-5,5-3) | 42 | |||
| 11/5/2022 | South Florida | 28 | at | Temple (3-9,1-7) | 54 | |||
| 11/12/2022 | SMU (7-6,5-3) | 41 | at | South Florida | 23 | |||
| 11/18/2022 | South Florida | 42 | at | Tulsa (5-7,3-5) | 48 | |||
| 11/26/2022 | UCF (9-5,6-3) | 46 | at | South Florida | 39 |
| vs South Florida | vs Other Opponents | South Florida compared to OOs | |
| Record: | 11-1 | 77-65 | |
| Points Scored: | 41.17 | 30.34 | -10.83 |
| Points Allowed: | 28.00 | 26.89 | 1.11 |
| Margin: | 13.17 | 3.45 | -9.72 |
| Total Points: | 69.17 | 57.23 | 11.94 |