| 9/1/2022 | New Mexico State (7-6) | 0 | at | Minnesota | 38 | Ind | ||
| 9/10/2022 | Western Illinois (0-11) | 10 | at | Minnesota | 62 | MVC (1AA) | ||
| 9/17/2022 | Colorado (1-11) | 7 | at | Minnesota | 49 | P12 | ||
| 9/24/2022 | Minnesota | 34 | at | Michigan State (5-7,3-6) | 7 | |||
| 10/1/2022 | Purdue (8-6,6-4) | 20 | at | Minnesota | 10 | |||
| 10/15/2022 | Minnesota | 14 | at | Illinois (8-5,5-4) | 26 | |||
| 10/22/2022 | Minnesota | 17 | at | Penn State (11-2,7-2) | 45 | |||
| 10/29/2022 | Rutgers (4-8,1-8) | 0 | at | Minnesota | 31 | |||
| 11/5/2022 | Minnesota | 20 | at | Nebraska (4-8,3-6) | 13 | |||
| 11/12/2022 | Northwestern (1-11,1-8) | 3 | at | Minnesota | 31 | |||
| 11/19/2022 | Iowa (8-5,5-4) | 13 | at | Minnesota | 10 | |||
| 11/26/2022 | Minnesota | 23 | at | Wisconsin (7-6,4-5) | 16 | |||
| 12/29/2022 | Syracuse (7-6) | 20 | vs | Minnesota | 28 | Bronx NY | ACC |
| vs Minnesota | vs Other Opponents | Minnesota compared to OOs | |
| Record: | 4-9 | 67-83 | |
| Points Scored: | 13.85 | 23.39 | 9.54 |
| Points Allowed: | 28.23 | 25.18 | 3.05 |
| Margin: | -14.38 | -1.79 | 12.59 |
| Total Points: | 42.08 | 48.57 | -6.49 |