| 9/3/2022 | Western Carolina | 52 | at | Charleston Southern (2-8) | 38 | at BigS | ||
| 9/10/2022 | Western Carolina | 17 | at | Georgia Tech (5-7) | 35 | at ACC | ||
| 9/17/2022 | Presbyterian (1-10) | 21 | at | Western Carolina | 77 | Pio | ||
| 9/24/2022 | Western Carolina | 12 | at | Samford (11-2,8-0) | 35 | |||
| 10/1/2022 | VMI (1-10,0-8) | 17 | at | Western Carolina | 38 | |||
| 10/8/2022 | Western Carolina | 6 | at | Mercer (7-4,5-3) | 49 | |||
| 10/15/2022 | Western Carolina | 40 | at | Furman (10-3,7-1) | 47 | |||
| 10/22/2022 | The Citadel (4-7,3-5) | 34 | at | Western Carolina | 21 | |||
| 11/5/2022 | Wofford (3-8,3-5) | 29 | at | Western Carolina | 36 | |||
| 11/12/2022 | Western Carolina | 20 | at | East Tennessee St (3-8,1-7) | 17 | |||
| 11/19/2022 | Chattanooga (7-4,5-3) | 29 | at | Western Carolina | 32 |
| vs Western Carolina | vs Other Opponents | Western Carolina compared to OOs | |
| Record: | 5-6 | 49-65 | |
| Points Scored: | 31.91 | 24.18 | -7.73 |
| Points Allowed: | 31.91 | 28.17 | 3.74 |
| Margin: | 0.00 | -3.99 | -3.99 |
| Total Points: | 63.82 | 52.35 | 11.47 |