| 9/1/2022 | Eastern Illinois | 27 | at | Northern Illinois | 34 | @ MAC (1A) | ||
| Western Illinois | 25 | at | Tennessee-Martin | 42 | MVC | |||
| 9/2/2022 | Tennessee Tech | 10 | at | Kansas | 56 | @ B12 (1A) | ||
| 9/3/2022 | Tennessee State | 29 | at | Eastern Washington | 36 | @ BSky | ||
| SE Missouri State | 10 | at | Iowa State | 42 | @ B12 (1A) | |||
| Murray State | 10 | at | Texas Tech | 63 | @ B12 (1A) | |||
| 9/8/2022 | Tennessee-Martin | 30 | at | Missouri State | 35 | @ MVC | ||
| 9/10/2022 | Chattanooga | 38 | at | Eastern Illinois | 20 | SoCon | ||
| Lindenwood | 21 | at | Houston Christian | 20 | @ SLC | |||
| Jacksonville State | 34 | at | Murray State | 3 | ASUN | |||
| SE Missouri State | 34 | at | Southern Illinois | 31 | @ MVC | |||
| Jackson State | 16 | vs | Tennessee State | 3 | Memphis TN | vs SWAC | ||
| Texas A&M-Commerce | 25 | at | Tennessee Tech | 26 | SLC | |||
| 9/17/2022 | Murray State | 0 | at | Ball State | 31 | @ MAC (1A) | ||
| Tennessee-Martin | 7 | at | Boise State | 30 | @ MW (1A) | |||
| Eastern Illinois | 7 | at | Illinois State | 35 | @ MVC | |||
| Keiser | 3 | at | Lindenwood | 37 | Sun (NAIA) | |||
| Tennessee State | 6 | at | Middle Tenn State | 49 | @ CUSA (1A) | |||
| Nicholls State | 16 | at | SE Missouri State | 42 | SLC | |||
| Samford | 33 | at | Tennessee Tech | 28 | SoCon | |||
| 9/24/2022 | Eastern Illinois | 35 | at | Murray State | 21 | |||
| Central Arkansas | 27 | at | SE Missouri State | 35 | ASUN | |||
| Lindenwood | 26 | at | Tennessee-Martin | 56 | ||||
| 10/1/2022 | SE Missouri State | 49 | at | Lindenwood | 28 | |||
| Murray State | 14 | at | Southeastern Louisiana | 48 | @ SLC | |||
| Lane | 28 | at | Tennessee State | 27 | OT | SIAC (D2) | ||
| Tennessee Tech | 28 | at | Tennessee-Martin | 45 | ||||
| 10/8/2022 | Lindenwood | 52 | at | Central Arkansas | 49 | @ ASUN | ||
| Northwestern State | 27 | at | Eastern Illinois | 35 | SLC | |||
| Tennessee-Martin | 45 | at | Murray State | 16 | ||||
| Tennessee Tech | 20 | at | SE Missouri State | 34 | ||||
| Bethune-Cookman | 17 | at | Tennessee State | 41 | SWAC | |||
| 10/15/2022 | Murray State | 17 | at | Austin Peay | 52 | @ ASUN | ||
| Lindenwood | 37 | at | Eastern Illinois | 34 | OT | |||
| Tennessee State | 30 | at | Tennessee Tech | 14 | ||||
| 10/22/2022 | Tennessee Tech | 30 | at | Kennesaw St | 33 | OT | @ ASUN | |
| Murray State | 18 | at | Lindenwood | 33 | ||||
| SE Missouri State | 51 | at | Northwestern State | 16 | @ SLC | |||
| Tennessee-Martin | 24 | at | Tennessee | 65 | @ SEC (1A) | |||
| Eastern Illinois | 17 | at | Tennessee State | 37 | ||||
| 10/29/2022 | Tennessee Tech | 20 | at | Eastern Illinois | 17 | |||
| Tennessee-Martin | 52 | at | Houston Christian | 28 | @ SLC | |||
| William Jewell | 23 | at | Lindenwood | 64 | GLV (D2) | |||
| Tennessee State | 3 | at | Murray State | 19 | ||||
| Eastern Kentucky | 28 | at | SE Missouri State | 23 | ASUN | |||
| 11/5/2022 | Eastern Illinois | 15 | at | McNeese State | 29 | @ SLC | ||
| SE Missouri State | 42 | at | Tennessee State | 0 | ||||
| Lindenwood | 34 | at | Tennessee Tech | 35 | ||||
| Kennesaw St | 44 | at | Tennessee-Martin | 27 | ASUN | |||
| 11/12/2022 | SE Missouri State | 31 | at | Eastern Illinois | 7 | |||
| McKendree | 35 | at | Lindenwood | 63 | GLV (D2) | |||
| Robert Morris | 9 | at | Murray State | 27 | BigS | |||
| Tennessee Tech | 35 | at | North Alabama | 27 | @ ASUN | |||
| Tennessee-Martin | 20 | at | Tennessee State | 3 | ||||
| 11/19/2022 | Murray State | 22 | at | SE Missouri State | 52 | |||
| Tennessee State | 22 | at | Texas A&M-Commerce | 14 | @ SLC | |||
| North Carolina Central | 22 | at | Tennessee Tech | 20 | MEAC | |||
| Eastern Illinois | 31 | at | Tennessee-Martin | 34 | ||||
| 11/26/2022 | SE Missouri State | 24 | at | Montana | 34 | FCS Championship - Round 1 | @ BSky |