| 9/3/2022 | Tennessee State (4-7) | 29 | at | Eastern Washington | 36 | OVC | ||
| 9/10/2022 | Eastern Washington | 14 | at | Oregon (10-3) | 70 | at P12 | ||
| 9/24/2022 | Montana State (12-2,9-0) | 38 | at | Eastern Washington | 35 | |||
| 10/2/2022 | Eastern Washington | 17 | at | Florida (6-7) | 52 | at SEC | ||
| 10/8/2022 | Eastern Washington | 21 | at | Weber State (10-3,6-3) | 45 | |||
| 10/15/2022 | Sacramento State (12-1,8-0) | 52 | at | Eastern Washington | 28 | |||
| 10/22/2022 | Eastern Washington | 17 | at | Cal Poly (2-9,1-7) | 10 | |||
| 10/29/2022 | Portland State (4-7,3-5) | 38 | at | Eastern Washington | 35 | |||
| 11/5/2022 | Eastern Washington | 16 | at | Idaho (7-5,6-2) | 48 | |||
| 11/12/2022 | Eastern Washington | 7 | at | Montana (8-5,4-4) | 63 | |||
| 11/19/2022 | Northern Colorado (3-8,2-6) | 21 | at | Eastern Washington | 45 |
| vs Eastern Washington | vs Other Opponents | Eastern Washington compared to OOs | |
| Record: | 8-3 | 70-54 | |
| Points Scored: | 42.36 | 31.39 | -10.97 |
| Points Allowed: | 24.64 | 28.83 | -4.19 |
| Margin: | 17.72 | 2.56 | -15.16 |
| Total Points: | 67.00 | 60.22 | 6.78 |