| 8/27/2022 | Keiser | 44 | at | Warner U. (0-8,0-6) | 7 | |||
| 9/1/2022 | Keiser | 21 | at | Valdosta State (5-6) | 36 | at GSC | ||
| 9/10/2022 | Keiser | 8 | at | Mississippi College (4-7) | 26 | at GSC | ||
| 9/17/2022 | Keiser | 3 | at | Lindenwood (7-3) | 37 | at OVC | ||
| 10/1/2022 | Florida Memorial (2-7,1-6) | 7 | at | Keiser | 48 | |||
| 10/8/2022 | Keiser | 36 | at | St Thomas FL (8-2,6-1) | 31 | |||
| 10/15/2022 | Warner U. (0-8,0-6) | 7 | at | Keiser | 56 | |||
| 10/22/2022 | Keiser | 40 | at | Southeastern FL (6-4,3-4) | 14 | |||
| 10/29/2022 | Ave Maria (5-3,3-2) | 21 | at | Keiser | 27 | |||
| 11/12/2022 | Keiser | 38 | at | Webber International (4-4,2-3) | 13 | |||
| 11/19/2022 | Keiser | 27 | at | Bethel TN (11-1) | 17 | NAIA Championship Round 1 | at MSC | |
| 11/26/2022 | Keiser | 29 | at | Morningside (11-1) | 28 | NAIA Quarterfinal | at GPAC | |
| 12/3/2022 | Keiser | 38 | at | Grand View (13-1) | 21 | NAIA Semifinals | at HAAC | |
| 12/17/2022 | Northwestern IA (13-1) | 35 | vs | Keiser | 25 | NAIA Championship - Durham NC | GPAC |
| vs Keiser | vs Other Opponents | Keiser compared to OOs | |
| Record: | 4-10 | 85-44 | |
| Points Scored: | 21.43 | 34.38 | 12.95 |
| Points Allowed: | 31.43 | 26.09 | 5.34 |
| Margin: | -10.00 | 8.29 | 18.29 |
| Total Points: | 52.86 | 60.47 | -7.61 |