| 8/27/2022 | Stephen F. Austin (6-5) | 17 | vs | Jacksonville State | 42 | Montgomery AL | WAC | |
| 9/3/2022 | Davidson (8-4) | 17 | at | Jacksonville State | 35 | Pio | ||
| 9/10/2022 | Jacksonville State | 34 | at | Murray State (2-9) | 3 | at OVC | ||
| 9/17/2022 | Jacksonville State | 17 | at | Tulsa (5-7) | 54 | at AAC | ||
| 9/24/2022 | Jacksonville State | 52 | at | Nicholls State (3-8) | 21 | at SLC | ||
| 10/1/2022 | Kennesaw St (5-6,1-4) | 28 | at | Jacksonville State | 35 | OT | ||
| 10/15/2022 | Jacksonville State | 47 | vs | North Alabama (1-10,0-5) | 31 | Madison AL | ||
| 10/22/2022 | Southeastern Louisiana (9-4) | 31 | at | Jacksonville State | 14 | SLC | ||
| 10/29/2022 | Jacksonville State | 40 | at | Austin Peay (7-4,3-2) | 16 | |||
| 11/12/2022 | Eastern Kentucky (7-5,3-2) | 17 | at | Jacksonville State | 42 | |||
| 11/19/2022 | Jacksonville State | 40 | at | Central Arkansas (5-6,3-2) | 17 |
| vs Jacksonville State | vs Other Opponents | Jacksonville State compared to OOs | |
| Record: | 2-9 | 56-59 | |
| Points Scored: | 22.91 | 30.03 | 7.12 |
| Points Allowed: | 36.18 | 31.54 | 4.64 |
| Margin: | -13.27 | -1.51 | 11.76 |
| Total Points: | 59.09 | 61.57 | -2.48 |