| 9/3/2022 | Nicholls State | 7 | at | South Alabama (10-3) | 48 | at SBC | ||
| 9/10/2022 | Nicholls State | 7 | at | UL Monroe (4-8) | 35 | at SBC | ||
| 9/17/2022 | Nicholls State | 16 | at | SE Missouri State (9-3) | 42 | at OVC | ||
| 9/24/2022 | Jacksonville State (9-2) | 52 | at | Nicholls State | 21 | ASUN | ||
| 10/1/2022 | Nicholls State | 33 | at | Northwestern State (4-7,4-2) | 36 | |||
| 10/8/2022 | Nicholls State | 19 | at | Houston Christian (2-9,1-5) | 17 | |||
| 10/15/2022 | Incarnate Word (12-2,6-1) | 49 | at | Nicholls State | 14 | |||
| 10/22/2022 | McNeese State (4-7,2-4) | 35 | at | Nicholls State | 40 | |||
| 10/29/2022 | Nicholls State | 17 | at | Lamar (1-10,1-5) | 24 | |||
| 11/12/2022 | Texas A&M-Commerce (5-6,3-3) | 10 | at | Nicholls State | 12 | |||
| 11/17/2022 | Southeastern Louisiana (9-4,5-1) | 40 | at | Nicholls State | 17 |
| vs Nicholls State | vs Other Opponents | Nicholls State compared to OOs | |
| Record: | 8-3 | 61-58 | |
| Points Scored: | 35.27 | 29.50 | -5.77 |
| Points Allowed: | 18.45 | 29.33 | -10.88 |
| Margin: | 16.82 | 0.17 | -16.65 |
| Total Points: | 53.72 | 58.83 | -5.11 |