| 9/1/2022 | Kennesaw St (5-6) | 17 | at | Samford | 27 | ASUN | ||
| 9/10/2022 | Samford | 0 | at | Georgia (15-0) | 33 | at SEC | ||
| 9/17/2022 | Samford | 33 | at | Tennessee Tech (4-7) | 28 | at OVC | ||
| 9/24/2022 | Western Carolina (6-5,4-4) | 12 | at | Samford | 35 | |||
| 10/1/2022 | Samford | 34 | at | Furman (10-3,7-1) | 27 | |||
| 10/8/2022 | Wofford (3-8,3-5) | 14 | at | Samford | 28 | |||
| 10/22/2022 | Samford | 55 | at | East Tennessee St (3-8,1-7) | 45 | |||
| 10/29/2022 | Samford | 38 | at | The Citadel (4-7,3-5) | 3 | |||
| 11/5/2022 | VMI (1-10,0-8) | 15 | at | Samford | 34 | |||
| 11/12/2022 | Samford | 35 | at | Chattanooga (7-4,5-3) | 24 | |||
| 11/19/2022 | Mercer (7-4,5-3) | 44 | at | Samford | 50 | 2OT | ||
| 12/3/2022 | Southeastern Louisiana (9-4) | 42 | at | Samford | 48 | OT | FCS Playoffs Round 2 | SLC |
| 12/9/2022 | Samford | 9 | at | North Dakota State (12-3) | 27 | FCS Quarterful | at MVC |
| vs Samford | vs Other Opponents | Samford compared to OOs | |
| Record: | 2-11 | 84-58 | |
| Points Scored: | 25.46 | 30.10 | 4.64 |
| Points Allowed: | 32.77 | 25.46 | 7.31 |
| Margin: | -7.31 | 4.64 | 11.95 |
| Total Points: | 58.23 | 55.56 | 2.67 |