| 8/27/2022 | Austin Peay | 27 | at | Western Kentucky (9-5) | 38 | at CUSA | ||
| 9/3/2022 | Presbyterian (1-10) | 0 | at | Austin Peay | 63 | Pio | ||
| 9/10/2022 | Mississippi Valley State (2-9) | 0 | at | Austin Peay | 41 | SWAC | ||
| 9/17/2022 | Austin Peay | 28 | at | Alabama A&M (4-7) | 3 | at SWAC | ||
| 9/24/2022 | Eastern Kentucky (7-5,3-2) | 20 | at | Austin Peay | 31 | |||
| 10/1/2022 | Austin Peay | 20 | at | Central Arkansas (5-6,3-2) | 49 | |||
| 10/15/2022 | Murray State (2-9) | 17 | at | Austin Peay | 52 | OVC | ||
| 10/29/2022 | Jacksonville State (9-2,5-0) | 40 | at | Austin Peay | 16 | |||
| 11/5/2022 | Austin Peay | 38 | at | North Alabama (1-10,0-5) | 35 | |||
| 11/12/2022 | Austin Peay | 31 | at | Kennesaw St (5-6,1-4) | 14 | |||
| 11/19/2022 | Austin Peay | 0 | at | Alabama (11-2) | 34 | at SEC |
| vs Austin Peay | vs Other Opponents | Austin Peay compared to OOs | |
| Record: | 4-7 | 52-64 | |
| Points Scored: | 22.73 | 28.61 | 5.88 |
| Points Allowed: | 31.55 | 31.42 | 0.13 |
| Margin: | -8.82 | -2.81 | 6.01 |
| Total Points: | 54.28 | 60.03 | -5.75 |