| 9/1/2022 | North Alabama | 14 | at | Indiana State (2-9) | 17 | OT | at MVC | |
| 9/10/2022 | Virginia-Wise (2-9) | 17 | at | North Alabama | 49 | SAC (D2) | ||
| 9/17/2022 | North Alabama | 14 | at | Chattanooga (7-4) | 41 | at SoCon | ||
| 9/24/2022 | Tarleton State (6-5) | 43 | at | North Alabama | 28 | WAC | ||
| 10/8/2022 | North Alabama | 34 | at | Kennesaw St (5-6,1-4) | 40 | 2OT | ||
| 10/15/2022 | Jacksonville State (9-2,5-0) | 47 | vs | North Alabama | 31 | Madison AL | ||
| 10/22/2022 | North Alabama | 53 | at | Eastern Kentucky (7-5,3-2) | 56 | |||
| 10/29/2022 | North Alabama | 29 | at | Central Arkansas (5-6,3-2) | 64 | |||
| 11/5/2022 | Austin Peay (7-4,3-2) | 38 | at | North Alabama | 35 | |||
| 11/12/2022 | Tennessee Tech (4-7) | 35 | at | North Alabama | 27 | OVC | ||
| 11/19/2022 | North Alabama | 0 | at | Memphis (7-6) | 59 | at AAC |
| vs North Alabama | vs Other Opponents | North Alabama compared to OOs | |
| Record: | 10-1 | 51-62 | |
| Points Scored: | 41.55 | 27.75 | -13.80 |
| Points Allowed: | 28.55 | 28.85 | -0.30 |
| Margin: | 13.00 | -1.10 | -14.10 |
| Total Points: | 70.10 | 56.60 | 13.50 |