| 9/3/2022 | Southeastern Louisiana | 7 | at | UL Lafayette (6-7) | 24 | at SBC | ||
| 9/10/2022 | Southeastern Louisiana | 9 | at | Florida Atlantic (5-7) | 42 | at CUSA | ||
| 9/17/2022 | Central Conn (2-9) | 6 | at | Southeastern Louisiana | 70 | NE | ||
| 9/24/2022 | Incarnate Word (12-2,6-1) | 35 | at | Southeastern Louisiana | 41 | |||
| 10/1/2022 | Murray State (2-9) | 14 | at | Southeastern Louisiana | 48 | OVC | ||
| 10/8/2022 | Texas A&M-Commerce (5-6,3-3) | 31 | at | Southeastern Louisiana | 28 | |||
| 10/22/2022 | Southeastern Louisiana | 31 | at | Jacksonville State (9-2) | 14 | at ASUN | ||
| 10/29/2022 | Southeastern Louisiana | 28 | at | McNeese State (4-7,2-4) | 27 | |||
| 11/5/2022 | Southeastern Louisiana | 47 | at | Lamar (1-10,1-5) | 31 | |||
| 11/12/2022 | Northwestern State (4-7,4-2) | 7 | at | Southeastern Louisiana | 23 | |||
| 11/17/2022 | Southeastern Louisiana | 40 | at | Nicholls State (3-8,3-4) | 17 | |||
| 11/26/2022 | Idaho (7-5) | 42 | at | Southeastern Louisiana | 45 | FCS Championship - Round 1 | BSky | |
| 12/3/2022 | Southeastern Louisiana | 42 | at | Samford (11-2) | 48 | OT | FCS Playoffs Round 2 | at SoCon |
| vs Southeastern Louisiana | vs Other Opponents | Southeastern Louisiana compared to OOs | |
| Record: | 4-9 | 67-72 | |
| Points Scored: | 26.00 | 28.19 | 2.19 |
| Points Allowed: | 35.31 | 28.04 | 7.27 |
| Margin: | -9.31 | 0.15 | 9.46 |
| Total Points: | 61.31 | 56.23 | 5.08 |