| 9/2/2022 | Eastern Kentucky | 34 | at | Eastern Michigan (9-4) | 42 | at MAC | ||
| 9/10/2022 | Eastern Kentucky | 59 | at | Bowling Green (6-7) | 57 | 7OT | at MAC | |
| 9/17/2022 | Charleston Southern (2-8) | 17 | at | Eastern Kentucky | 40 | BigS | ||
| 9/24/2022 | Eastern Kentucky | 20 | at | Austin Peay (7-4,3-2) | 31 | |||
| 10/1/2022 | Southern Utah (5-6) | 28 | at | Eastern Kentucky | 35 | WAC | ||
| 10/15/2022 | Sam Houston (5-4) | 25 | at | Eastern Kentucky | 17 | WAC | ||
| 10/22/2022 | North Alabama (1-10,0-5) | 53 | at | Eastern Kentucky | 56 | |||
| 10/29/2022 | Eastern Kentucky | 28 | at | SE Missouri State (9-3) | 23 | at OVC | ||
| 11/5/2022 | Central Arkansas (5-6,3-2) | 14 | at | Eastern Kentucky | 42 | |||
| 11/12/2022 | Eastern Kentucky | 17 | at | Jacksonville State (9-2,5-0) | 42 | |||
| 11/19/2022 | Kennesaw St (5-6,1-4) | 38 | at | Eastern Kentucky | 45 | |||
| 11/26/2022 | Gardner-Webb (7-6) | 52 | at | Eastern Kentucky | 41 | FCS Championship - Round 1 | BigS |
| vs Eastern Kentucky | vs Other Opponents | Eastern Kentucky compared to OOs | |
| Record: | 5-7 | 65-59 | |
| Points Scored: | 35.17 | 28.48 | -6.69 |
| Points Allowed: | 36.17 | 28.41 | 7.76 |
| Margin: | -1.00 | 0.07 | 1.07 |
| Total Points: | 71.34 | 56.89 | 14.45 |