| 9/1/2022 | McKendree | 31 | at | Northern Michigan (4-7) | 24 | OT | at GLIAC | |
| 9/10/2022 | Delta State (11-2) | 58 | at | McKendree | 34 | GSC | ||
| 9/17/2022 | McKendree | 38 | at | Lake Erie (3-8) | 37 | at GMAC | ||
| 9/24/2022 | Walsh (1-9) | 10 | at | McKendree | 46 | GMAC | ||
| 10/1/2022 | McKendree | 45 | at | William Jewell (2-9,1-5) | 34 | |||
| 10/8/2022 | Indianapolis (9-2,6-0) | 38 | at | McKendree | 23 | |||
| 10/15/2022 | Quincy (4-7,1-5) | 63 | at | McKendree | 62 | OT | ||
| 10/22/2022 | McKendree | 42 | at | Missouri S&T (3-7,2-4) | 35 | |||
| 10/29/2022 | Southwest Baptist (6-5,4-2) | 49 | at | McKendree | 31 | |||
| 11/5/2022 | McKendree | 7 | at | Truman State (9-2,5-1) | 52 | |||
| 11/12/2022 | McKendree | 35 | at | Lindenwood (7-3) | 63 | at OVC |
| vs McKendree | vs Other Opponents | McKendree compared to OOs | |
| Record: | 6-5 | 53-56 | |
| Points Scored: | 42.09 | 26.73 | -15.36 |
| Points Allowed: | 35.82 | 28.11 | 7.71 |
| Margin: | 6.27 | -1.38 | -7.65 |
| Total Points: | 77.91 | 54.84 | 23.07 |