| 9/3/2022 | North Carolina A&T (7-4) | 13 | vs | North Carolina Central | 28 | Charlotte NC | BigS | |
| 9/10/2022 | Winston-Salem State (3-6) | 0 | at | North Carolina Central | 41 | CIAA (D2) | ||
| 9/17/2022 | North Carolina Central | 45 | at | New Hampshire (9-4) | 27 | at CAAF | ||
| 9/24/2022 | Virginia U-Lynchburg (0-10) | 14 | at | North Carolina Central | 59 | None (Unk?) | ||
| 10/1/2022 | North Carolina Central | 18 | at | Campbell (5-6) | 48 | at BigS | ||
| 10/13/2022 | Morgan State (4-7,2-3) | 20 | at | North Carolina Central | 59 | |||
| 10/22/2022 | North Carolina Central | 24 | at | South Carolina State (3-8,1-4) | 26 | |||
| 10/29/2022 | North Carolina Central | 28 | at | Delaware State (5-6,2-3) | 21 | |||
| 11/5/2022 | Howard (5-6,4-1) | 21 | at | North Carolina Central | 50 | |||
| 11/12/2022 | North Carolina Central | 48 | at | Norfolk State (2-9,2-3) | 14 | |||
| 11/19/2022 | North Carolina Central | 22 | at | Tennessee Tech (4-7) | 20 | at OVC | ||
| 12/17/2022 | Jackson State (12-1) | 34 | vs | North Carolina Central | 41 | OT | Atlanta GA | SWAC |
| vs North Carolina Central | vs Other Opponents | North Carolina Central compared to OOs | |
| Record: | 2-10 | 57-64 | |
| Points Scored: | 21.50 | 24.79 | 3.29 |
| Points Allowed: | 38.58 | 27.32 | 11.26 |
| Margin: | -17.08 | -2.53 | 14.55 |
| Total Points: | 60.08 | 52.11 | 7.97 |