| 9/1/2022 | Colorado Mesa (4-6) | 37 | at | William Jewell | 14 | RMAC | ||
| 9/10/2022 | William Jewell | 19 | at | Black Hills State (7-4) | 38 | at RMAC | ||
| 9/17/2022 | William Jewell | 21 | at | Ohio Dominican (7-3) | 31 | at GMAC | ||
| 9/24/2022 | Kentucky Wesleyan (2-9) | 17 | at | William Jewell | 24 | GMAC | ||
| 10/1/2022 | McKendree (5-6,2-4) | 45 | at | William Jewell | 34 | |||
| 10/8/2022 | William Jewell | 21 | at | Southwest Baptist (6-5,4-2) | 44 | |||
| 10/15/2022 | Missouri S&T (3-7,2-4) | 41 | at | William Jewell | 14 | |||
| 10/22/2022 | Truman State (9-2,5-1) | 42 | at | William Jewell | 7 | |||
| 10/29/2022 | William Jewell | 23 | at | Lindenwood (7-3) | 64 | at OVC | ||
| 11/5/2022 | Indianapolis (9-2,6-0) | 48 | at | William Jewell | 14 | |||
| 11/12/2022 | William Jewell | 17 | at | Quincy (4-7,1-5) | 7 |
| vs William Jewell | vs Other Opponents | William Jewell compared to OOs | |
| Record: | 9-2 | 54-52 | |
| Points Scored: | 37.64 | 29.28 | -8.36 |
| Points Allowed: | 18.91 | 29.86 | -10.95 |
| Margin: | 18.73 | -0.58 | -19.31 |
| Total Points: | 56.55 | 59.14 | -2.59 |