| 9/1/2022 | Missouri State | 27 | at | Central Arkansas (5-6) | 14 | at ASUN | ||
| 9/8/2022 | Tennessee-Martin (7-4) | 30 | at | Missouri State | 35 | OVC | ||
| 9/17/2022 | Missouri State | 27 | at | Arkansas (7-6) | 38 | at SEC | ||
| 9/24/2022 | South Dakota State (14-1,9-0) | 28 | at | Missouri State | 14 | |||
| 10/1/2022 | Missouri State | 31 | at | North Dakota (7-5,5-3) | 48 | |||
| 10/8/2022 | Southern Illinois (5-6,4-4) | 38 | at | Missouri State | 21 | |||
| 10/22/2022 | Missouri State | 20 | at | Northern Iowa (6-5,5-3) | 41 | |||
| 10/29/2022 | Western Illinois (0-11,0-8) | 14 | at | Missouri State | 64 | |||
| 11/5/2022 | Missouri State | 13 | at | South Dakota (3-8,2-6) | 20 | |||
| 11/12/2022 | Youngstown State (7-4,5-3) | 22 | at | Missouri State | 25 | |||
| 11/19/2022 | Missouri State | 24 | at | Indiana State (2-9,1-7) | 7 |
| vs Missouri State | vs Other Opponents | Missouri State compared to OOs | |
| Record: | 6-5 | 57-60 | |
| Points Scored: | 27.27 | 27.59 | 0.32 |
| Points Allowed: | 27.36 | 28.62 | -1.26 |
| Margin: | -0.09 | -1.03 | -0.94 |
| Total Points: | 54.63 | 56.21 | -1.58 |