| 9/4/2022 | Florida A&M (9-2,7-1) | 3 | vs | Jackson State | 59 | | Miami Gardens FL | |
| 9/10/2022 | Jackson State | 16 | vs | Tennessee State (4-7) | 3 | | Memphis TN | vs OVC |
| 9/17/2022 | Grambling (3-8,2-7) | 24 | at | Jackson State | 66 | | | |
| 9/24/2022 | Mississippi Valley State (2-9,2-6) | 7 | at | Jackson State | 49 | | | |
| 10/8/2022 | Jackson State | 26 | at | Alabama State (6-5,4-4) | 12 | | | |
| 10/15/2022 | Jackson State | 48 | vs | Bethune-Cookman (2-9,2-6) | 8 | | Jacksonville FL | |
| 10/22/2022 | Campbell (5-6) | 14 | at | Jackson State | 22 | | | BigS |
| 10/29/2022 | Southern (7-5,5-4) | 0 | at | Jackson State | 35 | | | |
| 11/5/2022 | Jackson State | 41 | at | Texas Southern (5-6,4-4) | 14 | | | |
| 11/12/2022 | Alabama A&M (4-7,4-4) | 13 | vs | Jackson State | 27 | | Mobile AL | |
| 11/19/2022 | Jackson State | 24 | at | Alcorn State (5-6,4-4) | 13 | | | |
| 12/3/2022 | Southern (7-5,5-4) | 24 | at | Jackson State | 43 | | SWAC Championship | |
| 12/17/2022 | Jackson State | 34 | vs | North Carolina Central (10-2) | 41 | OT | Atlanta GA | vs MEAC |