| 9/3/2022 | Northwestern State | 0 | at | Montana (8-5) | 47 | at BSky | ||
| 9/10/2022 | Northwestern State | 21 | vs | Grambling (3-8) | 47 | Shreveport LA | vs SWAC | |
| 9/17/2022 | Northwestern State | 10 | at | Southern Miss (7-6) | 64 | at SBC | ||
| 9/24/2022 | Lamar (1-10,1-5) | 27 | at | Northwestern State | 35 | |||
| 10/1/2022 | Nicholls State (3-8,3-4) | 33 | at | Northwestern State | 36 | |||
| 10/8/2022 | Northwestern State | 27 | at | Eastern Illinois (2-9) | 35 | at OVC | ||
| 10/15/2022 | Northwestern State | 37 | at | Houston Christian (2-9,1-5) | 10 | |||
| 10/22/2022 | SE Missouri State (9-3) | 51 | at | Northwestern State | 16 | OVC | ||
| 11/5/2022 | Northwestern State | 41 | at | Texas A&M-Commerce (5-6,3-3) | 14 | |||
| 11/12/2022 | Northwestern State | 7 | at | Southeastern Louisiana (9-4,5-1) | 23 | |||
| 11/19/2022 | Incarnate Word (12-2,6-1) | 66 | at | Northwestern State | 7 |
| vs Northwestern State | vs Other Opponents | Northwestern State compared to OOs | |
| Record: | 7-4 | 54-66 | |
| Points Scored: | 37.91 | 28.50 | -9.41 |
| Points Allowed: | 21.55 | 28.62 | -7.07 |
| Margin: | 16.36 | -0.12 | -16.48 |
| Total Points: | 59.46 | 57.12 | 2.34 |