| 9/1/2022 | Eastern Illinois (2-9) | 27 | at | Northern Illinois | 34 | OVC (1AA) | ||
| 9/10/2022 | Northern Illinois | 35 | at | Tulsa (5-7) | 38 | at AAC | ||
| 9/17/2022 | Vanderbilt (5-7) | 38 | at | Northern Illinois | 28 | SEC | ||
| 9/24/2022 | Northern Illinois | 23 | at | Kentucky (7-6) | 31 | at SEC | ||
| 10/1/2022 | Northern Illinois | 38 | at | Ball State (5-7,3-5) | 44 | 2OT | ||
| 10/8/2022 | Toledo (9-5,6-3) | 52 | at | Northern Illinois | 32 | |||
| 10/15/2022 | Northern Illinois | 39 | at | Eastern Michigan (9-4,5-3) | 10 | |||
| 10/22/2022 | Northern Illinois | 17 | at | Ohio (10-4,7-2) | 24 | |||
| 11/2/2022 | Central Michigan (4-8,3-5) | 35 | at | Northern Illinois | 22 | |||
| 11/9/2022 | Northern Illinois | 24 | at | Western Michigan (5-7,4-4) | 21 | |||
| 11/16/2022 | Miami-Ohio (6-7,4-4) | 29 | at | Northern Illinois | 23 | |||
| 11/26/2022 | Akron (2-10,1-7) | 44 | at | Northern Illinois | 12 |
| vs Northern Illinois | vs Other Opponents | Northern Illinois compared to OOs | |
| Record: | 9-3 | 60-78 | |
| Points Scored: | 32.75 | 24.47 | -8.28 |
| Points Allowed: | 27.25 | 27.96 | -0.71 |
| Margin: | 5.50 | -3.49 | -8.99 |
| Total Points: | 60.00 | 52.43 | 7.57 |